The objective of the present study was to prepare the floating tablets of opioid-receptor agonist loperamide. Floating tablets constitute an innovative dosage form that overcome the problems of large frequency of dosing and provides a sustained action for a longer period of time. In the view of enhancing bioavailability an attempt has been made to prepare floating tablets and to know the effect of different grades of polymers and also different types of polymers on formulations. Floating tablets were prepared by direct compression method using different polymers like HPMC K4M, HPMC K15M HPMC K100M. The prepared tablets were evaluated for pre-compression and post compression parameters. All the formulations showed low weight variation with sustained release of drug. The physical properties like hardness, friability and drug content of all the formulations were within the acceptable limits. The selected F9 formulations were subjected to stability studies at 40±2°C or 75±5% RH for 30 days.
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